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Although vitamin B12 is essential during pregnancy, too much can harm the fetus Vitamin B12 deficiency is associated with negative pregnancy outcomes, according to a 2021 review of then-existing scientific literature on B12 deficiency in the Indian population (via Frontiers in Endocrinology)

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On the other hand, knocking down DJ-1 exacerbates the cell death induced by oxidative stress, as well as in response to other insults such as endoplasmic reticulum (ER) stress, proteasome inhibition and calcium entry [342, 348, 349]